Immuno Oncology Models
Subcutaneous CT26 Mouse Colon Carcinoma
Validated subcutaneous models with positive control immune checkpoint inhibitors
% Tumor Growth Inhibition relative to vehicle @ d25
**p<0.01 relative to saline & isotype control
*p<0.01 relative to saline
Additional tumor growth curves with standard-of-care treatments also available
MC38 Mouse Colon Carcinoma
Tumor growth kinetics evaluated at 5 different cell implant conditions
Efficacy evaluation includes daily dosing of test articles, twice weekly body weights, tumor volumes and clinical observations for up to 5 weeks
4T1 Mouse Mammary Carcinoma
Validated subcutaneous, mammary fat pad orthotopic, and intravenous lung primary tumor implants, with secondary metastatic lung evaluations available
Time to Evaluation Size for 300 mm3 and 1000 mm3 calculations performed
Ll/2 Mouse Lung Carcinoma
C57Bl/6 mice are implanted with 0.3 million cells subcutaneously on the right hind flank
Tumor volumes and body weights are measured twice weekly
Orthotopic Mouse Models
Validated sites of orthotopic implant include:
Intracranial
Intrasplenic
Colon (intra-cecal)
Mammary Fat Pad
Direct Lung Injection
Humanized Mouse Models
PBMC or CD34+ Engrafted Mice
Tumor growth evaluation with immune checkpoint inhibitors
PBMC Graft versus Host Disease models also available